cometchip raw data and analyzed results, part six Search Results


keyence software  (KEYENCE)
90
KEYENCE keyence software
Keyence Software, supplied by KEYENCE, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/keyence software/product/KEYENCE
Average 90 stars, based on 1 article reviews
keyence software - by Bioz Stars, 2026-05
90/100 stars
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cometchip® assay  (Lonza)
90
Lonza cometchip® assay
Cometchip® Assay, supplied by Lonza, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/cometchip® assay/product/Lonza
Average 90 stars, based on 1 article reviews
cometchip® assay - by Bioz Stars, 2026-05
90/100 stars
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cometchip  (Trevigen)
86
Trevigen cometchip
Cometchip, supplied by Trevigen, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/cometchip/product/Trevigen
Average 86 stars, based on 1 article reviews
cometchip - by Bioz Stars, 2026-05
86/100 stars
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cometchip ® analysis  (Integrated Laboratory Systems Inc)
90
Integrated Laboratory Systems Inc cometchip ® analysis
DNA damage in human HepaRG™ cells measured using the alkaline <t>CometChip</t> ® assay. Cells were exposed to increasing concentrations of DNA damage-inducing (DDI; A–I) and non-DDI test chemicals (J–L) . Median % tail DNA is shown 4 h following the last exposure. The data are expressed as the median % tail DNA ± SE ( n = 4). Red bars represent Group 1 DDI chemicals, blue bars denote the Group 2 non-DDI chemical and the Group 3 potentially misleading positive chemicals. Diagonal lines indicate overtly cytotoxic concentrations. Note the difference in the scale of the y-axis for MMS, ENU, and ZDV due to the large magnitude of the response for these three DDI (Group 1) chemicals. * P < 0.05, ** P < 0.001 compared to matched vehicle control.
Cometchip ® Analysis, supplied by Integrated Laboratory Systems Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/cometchip ® analysis/product/Integrated Laboratory Systems Inc
Average 90 stars, based on 1 article reviews
cometchip ® analysis - by Bioz Stars, 2026-05
90/100 stars
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celigo s imaging cytometer  (Nexcelom Bioscience)
90
Nexcelom Bioscience celigo s imaging cytometer
DNA damage in human HepaRG™ cells measured using the alkaline <t>CometChip</t> ® assay. Cells were exposed to increasing concentrations of DNA damage-inducing (DDI; A–I) and non-DDI test chemicals (J–L) . Median % tail DNA is shown 4 h following the last exposure. The data are expressed as the median % tail DNA ± SE ( n = 4). Red bars represent Group 1 DDI chemicals, blue bars denote the Group 2 non-DDI chemical and the Group 3 potentially misleading positive chemicals. Diagonal lines indicate overtly cytotoxic concentrations. Note the difference in the scale of the y-axis for MMS, ENU, and ZDV due to the large magnitude of the response for these three DDI (Group 1) chemicals. * P < 0.05, ** P < 0.001 compared to matched vehicle control.
Celigo S Imaging Cytometer, supplied by Nexcelom Bioscience, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/celigo s imaging cytometer/product/Nexcelom Bioscience
Average 90 stars, based on 1 article reviews
celigo s imaging cytometer - by Bioz Stars, 2026-05
90/100 stars
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comet analysis software  (Trevigen)
86
Trevigen comet analysis software
DNA damage in human HepaRG™ cells measured using the alkaline <t>CometChip</t> ® assay. Cells were exposed to increasing concentrations of DNA damage-inducing (DDI; A–I) and non-DDI test chemicals (J–L) . Median % tail DNA is shown 4 h following the last exposure. The data are expressed as the median % tail DNA ± SE ( n = 4). Red bars represent Group 1 DDI chemicals, blue bars denote the Group 2 non-DDI chemical and the Group 3 potentially misleading positive chemicals. Diagonal lines indicate overtly cytotoxic concentrations. Note the difference in the scale of the y-axis for MMS, ENU, and ZDV due to the large magnitude of the response for these three DDI (Group 1) chemicals. * P < 0.05, ** P < 0.001 compared to matched vehicle control.
Comet Analysis Software, supplied by Trevigen, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/comet analysis software/product/Trevigen
Average 86 stars, based on 1 article reviews
comet analysis software - by Bioz Stars, 2026-05
86/100 stars
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Image Search Results


DNA damage in human HepaRG™ cells measured using the alkaline CometChip ® assay. Cells were exposed to increasing concentrations of DNA damage-inducing (DDI; A–I) and non-DDI test chemicals (J–L) . Median % tail DNA is shown 4 h following the last exposure. The data are expressed as the median % tail DNA ± SE ( n = 4). Red bars represent Group 1 DDI chemicals, blue bars denote the Group 2 non-DDI chemical and the Group 3 potentially misleading positive chemicals. Diagonal lines indicate overtly cytotoxic concentrations. Note the difference in the scale of the y-axis for MMS, ENU, and ZDV due to the large magnitude of the response for these three DDI (Group 1) chemicals. * P < 0.05, ** P < 0.001 compared to matched vehicle control.

Journal: Frontiers in Public Health

Article Title: A Modern Genotoxicity Testing Paradigm: Integration of the High-Throughput CometChip® and the TGx-DDI Transcriptomic Biomarker in Human HepaRG™ Cell Cultures

doi: 10.3389/fpubh.2021.694834

Figure Lengend Snippet: DNA damage in human HepaRG™ cells measured using the alkaline CometChip ® assay. Cells were exposed to increasing concentrations of DNA damage-inducing (DDI; A–I) and non-DDI test chemicals (J–L) . Median % tail DNA is shown 4 h following the last exposure. The data are expressed as the median % tail DNA ± SE ( n = 4). Red bars represent Group 1 DDI chemicals, blue bars denote the Group 2 non-DDI chemical and the Group 3 potentially misleading positive chemicals. Diagonal lines indicate overtly cytotoxic concentrations. Note the difference in the scale of the y-axis for MMS, ENU, and ZDV due to the large magnitude of the response for these three DDI (Group 1) chemicals. * P < 0.05, ** P < 0.001 compared to matched vehicle control.

Article Snippet: The chemical exposures in HepaRGTM cells, the cell viability studies, and the paired high-throughput CometChip ® analysis were conducted at Integrated Laboratory Systems, Inc. (ILS; Research Triangle Park, Durham, NC, USA).

Techniques: Control

Summary of CometChip ® analysis and TempO-Seq ® TGx-DDI classification results for 12 test chemicals.

Journal: Frontiers in Public Health

Article Title: A Modern Genotoxicity Testing Paradigm: Integration of the High-Throughput CometChip® and the TGx-DDI Transcriptomic Biomarker in Human HepaRG™ Cell Cultures

doi: 10.3389/fpubh.2021.694834

Figure Lengend Snippet: Summary of CometChip ® analysis and TempO-Seq ® TGx-DDI classification results for 12 test chemicals.

Article Snippet: The chemical exposures in HepaRGTM cells, the cell viability studies, and the paired high-throughput CometChip ® analysis were conducted at Integrated Laboratory Systems, Inc. (ILS; Research Triangle Park, Durham, NC, USA).

Techniques: Gene Expression

Comparison of benchmark concentrations for CometChip ® (BMC CC ) and TGx-DDI biomarker genes (BMC TGx ).

Journal: Frontiers in Public Health

Article Title: A Modern Genotoxicity Testing Paradigm: Integration of the High-Throughput CometChip® and the TGx-DDI Transcriptomic Biomarker in Human HepaRG™ Cell Cultures

doi: 10.3389/fpubh.2021.694834

Figure Lengend Snippet: Comparison of benchmark concentrations for CometChip ® (BMC CC ) and TGx-DDI biomarker genes (BMC TGx ).

Article Snippet: The chemical exposures in HepaRGTM cells, the cell viability studies, and the paired high-throughput CometChip ® analysis were conducted at Integrated Laboratory Systems, Inc. (ILS; Research Triangle Park, Durham, NC, USA).

Techniques: Comparison, Biomarker Discovery

Relationship between the BMCs of the CometChip ® data (BMC CC ) and the TGx-DDI biomarker genes (BMC TGx ) for the test chemicals that yielded positive hazard calls in both tests and could be modeled. Specifically, the BMC CC with a BMR of 1SD with two-sided 95% CIs are shown for the CometChip ® vs. median bootstrap BMC TGX (BMR of 1SD) with two-sided 95% CIs for the TGx-DDI biomarker classification endpoint. The BMCs for the agents that were classified as DDI from both approaches were within 10-fold. The two parallel black lines with intercepts of 1 and −1 on the double log10 scale represent a 10-fold deviation from the 1:1 line.

Journal: Frontiers in Public Health

Article Title: A Modern Genotoxicity Testing Paradigm: Integration of the High-Throughput CometChip® and the TGx-DDI Transcriptomic Biomarker in Human HepaRG™ Cell Cultures

doi: 10.3389/fpubh.2021.694834

Figure Lengend Snippet: Relationship between the BMCs of the CometChip ® data (BMC CC ) and the TGx-DDI biomarker genes (BMC TGx ) for the test chemicals that yielded positive hazard calls in both tests and could be modeled. Specifically, the BMC CC with a BMR of 1SD with two-sided 95% CIs are shown for the CometChip ® vs. median bootstrap BMC TGX (BMR of 1SD) with two-sided 95% CIs for the TGx-DDI biomarker classification endpoint. The BMCs for the agents that were classified as DDI from both approaches were within 10-fold. The two parallel black lines with intercepts of 1 and −1 on the double log10 scale represent a 10-fold deviation from the 1:1 line.

Article Snippet: The chemical exposures in HepaRGTM cells, the cell viability studies, and the paired high-throughput CometChip ® analysis were conducted at Integrated Laboratory Systems, Inc. (ILS; Research Triangle Park, Durham, NC, USA).

Techniques: Biomarker Discovery